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Frequently asked questions

I got my ancestry information. Can I now use my data to get LifeNome reports?

Absolutely! LifeNome uses DNA data from 23andMe, AncestryDNA and FamilyTreeDNA to provide you with the most accurate genetic-based reports. If you have your ancestry information from 23andMe, you just need to authorize your data transfer. You can also download your 23andMe, AncestryDNA or FamilyTreeDNA data results to your computer, and upload your data to LifeNome portal to get your DNA-based reports. See below for detailed instructions.

How to access and download your DNA results from 23andme?

You can access your raw genetic data within your 23andMe account one of two ways:

  1. Navigate directly to you.23andme.com/tools/data/
  2. To download your raw data, click on the Download tab from within the top navigation bar within the Browse Raw Data tool and scroll down until you see the “Submit request” button. You will receive an email to the email address associated with your 23andMe account when your raw data download file is ready. Typically files are ready within 1 hour.
  3. You will be emailed when the file is ready to download. Just follow the instructions provided in the “Your 23andMe raw data download is ready!” email.
  4. Note where you save the Raw Data file on your computer.
  5. Go to your Lifenome.com account and upload your data.
  6. Get your DNA-based LifeNome reports!
How to access and download your DNA results from FamilyTreeDNA™?
  1. Sign in to your myFTDNA account
  2. On the menu bar, click myFTDNA > MyDNA > Family Finder > Download Raw Data
  3. Download the file Build 37 Raw Data Concatenated (in CSV format). Remember that these files are typically in a zipped format and you will need to unzip to access the CSV file.
  4. Note where you save the Raw Data file on your computer.
  5. Go to your Lifenome.com account and upload your data.
    Get your DNA-based Lifenome reports!
How to access and download your DNA results from AncestryDNA™?
  1. Sign in to your Ancestry.com account
  2. On the menu bar, click DNA > Your DNA Results Summary.
  3. On the right side of the page, click Settings. Scroll down the Test Settings page.
  4. On the right side of the page, in the Download your raw DNA data section, click Get Started. Enter your password in the empty field.
  5. Check your email for an email from AncestryDNA with the subject line Your request to download AncestryDNA raw data.
  6. In the email, click Confirm Data Download. You will be redirected to the Ancestry.com website.
  7. Enter your username or email and password in the appropriate fields, and click Sign In. The Download DNA Raw Data page is displayed.
  8. Click Download DNA Raw Data to download your raw data file. Note where you save the file on your computer.
  9. Go to your Lifenome.com account and upload your AncestryDNA data.
  10. Get your DNA-based Lifenome reports!

Section

What is a genetic variant?

Your DNA controls everything about you: from your eye color, sensitivity to sun, and risks of complex diseases. Knowledge of your genetics can be utilized for preventive purposes, leading to healthier life and personalized daily choices. Genetic variations in our DNA impact the way your body processes nutrients, your muscles and joints structure, your skin characteristics, and many other wellness traits, from predisposition to higher blood pressure due to excessive salt consumption, or negative impact of trans-fats.

What is a genetic predisposition?

Wellness Genomics is the science of identifying associations between genetic variations wellness traits identifying associations between genetic variations. This is called predisposition likelihood assessment. LifeNome uses a Computational Genomics engine that assesses the cumulative effect of genetic variations that may impact your wellness traits based on thousands of peer-reviewed genetic studies of various populations and provides you with state of the art predisposition likelihood assessment for that trait.

Why is our science superior to all the other companies offering similar tests?

Most companies you will see use single genetic variations that are available in publicly available studies to assess whether or not you may have a predisposition. There are many problems with this approach. For one you may have multiple genetic variations that are associated with a wellness trait and still have low predisposition likelihood for that trait. This can be because some genetic variations have a lower influence on the total likelihood for some ethnicity than another, and it can also be because there are inhibiting variations that balance the impact of the contributing variations. Our technology looks at genetic patterns cumulatively impacting a cluster of genetic traits and is enhanced by a learning artificial intelligence algorithm that automatically adds new scientific knowledge as it becomes available and gets smarter as it absorbs new genotype-phenotype data.

How accurate is it?

There are many things to consider when reading your genetics-based wellness assessment. Most wellness traits are influenced by three components: your genetics, your nurture environment (ages 0-7) and your current lifestyle choices. As such, Genetics is not the only determinant for the actual presence of a trait. Genetic predispositions can only tell you the statistical likelihood that you are predisposed to a particular trait such as vitamin deficiency or skin youthfulness. Additionally, many of the large-scale studies performed have been done primarily on European populations.

While most genetic traits are affected by the same genetic variations regardless of ethnicity, the degree of influence of each genetic variation may vary across populations. We strive to keep up with the latest developments in the field of Wellness Genomics and we provide you with the most up-to-date information. Through the surveys we provide you with, we get more information about the actual state of your wellness for some of the traits for which you get your predisposition results and can thereby determine how much of a trait is genetically predictable based on predisposition likelihood analysis.

How can I trust the results?

The scientific studies chosen as an input for our knowledge base are highly curated peer reviewed studies with statistically significant populations and generalizability. As such the knowledge base is the most comprehensive and rigorous set of genomics studies available today. However, a predisposition likelihood model is a risk model and it provides likelihood assessments for a trait. It helps to make precautionary choices for lifestyle, which would allow to mitigate any potential adverse effects of a negative trait and taking advantage of a positive trait. Wellness Genomics is based on the same rigorous scientific principles as Personalized Medicine. As an example consider a well-known genetic variant rs429358 that significantly increases the risk for Alzheimer disease.

Having this variant, does not necessarily mean that a person has the disease, or will get the disease. It does, however, indicate the higher risk for a disease. Knowing this information may help the individual to take preventive action.  Similarly, genetic variations associated with decreased levels of an essential vitamin or mineral, indicate risk for potential micronutrient deficiency. An individual with higher genetic-based risk for deficiency in vitamin D, for example, is encouraged to consume foods rich in vitamin D, monitor vitamin D level, and talk to nutritionist  or healthcare provider about vitamin D supplementation. While everyone needs to make sure to follow general recommendations for all essential minerals and vitamins, it is even more important to monitor those for which you have elevated genetics-based risks.

Where can I find the scientific studies underlying the analysis?

For every trait we provide you with the list of genetic variations that are present in your DNA which impact the traits both contributing to the predisposition likelihood as well as protecting against it. When you click on those variations, you will be taken to further resources that provide all the studies linked to that variation and its linkage to the particular trait. We also provide  additional resources that you can use to study about the trait and the genetic variations further.

Why did you choose these genes and SNPs?

The genes and the SNPs are selected based on two criteria:

  1. the significance of the statistical relationship strength between the genetic variations and the trait within the scientific literature and
  2. the presence of that genetic variation within a genotype-phenotype cluster.
How do you arrive at the risk assessment?

The algorithm behind the scores is complex and proprietary, but the basic logic is as follows. First, there are potentially two types of genetic variations present for a single individual: those that contribute to the strength of a trait and those that decrease the strength of a trait. For example, within a single person there may be genetic variations that increase the likelihood that a person may be predisposed to obesity and there may be others that decrease that likelihood. We look at each genetic variation, determine its influence on the trait.

Weigh the importance given its potential role in critical metabolic pathways and enzymatic reactions, explore whether it is co-occurring with other variations that we expect to see if there is a higher risk and calculate a net likelihood score for the individual. Then we look at population data and rank the person based on where they are in terms of likelihood of predisposition compared to the rest of the population. The population percentile score shows the percentage of people who have less likelihood than the individual to be predisposed genetically to a trait.

How come some of the assessment doesn't match my observations? I exercise a lot since I was young, why does the result say I'm high in exercise aversion?

As discussed every trait has three components, nature (genetics), nurture (upbringing) and current lifestyle (choice/behavior). We generally report traits that have a strong genetic influence and which we can report reliably.  Sometimes a genetic predisposition runs in the family but does not express itself in your specific case.

​If you are predisposed to exercise aversion it means many people with the same genetic composition as yours found it more difficult to motivate themselves to exercise. Your family upbringing and personal choices can overcome your genetics. In fact, that is the main reason we offer you this information, since you can use it to overcome your potential predispositions through a change in lifestyle. If you are exercising despite being predisposed, you should be more proud of your achievement compared to someone that does not have a predisposition to exercise lethargy.