PERSONALISED SKIN, HAIR & SCALP CARE

Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organisation and compartmentalised sensitivity to distinct extrinsic ageing factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of ageing and other long-term skin and hair effects.

LifeNome’s DNA- personalised skin and hair care assessments and recommendations are providing a comprehensive understanding of individual’s skin and hair/scalp characteristics with the 30 selected traits using proprietary Genomics AI™ technology. The technology is incorporating the knowledge from thousands of scientific studies and is matching the personal skin and hair predispositions to the ingredients within the products for the skin and hair care. Individually tailored skin and hair care regimes could be automatically created to reflect the optimal plan for the individual

SKIN AND AGING

Skin changes as we age. Some people are exceptional agers: their skin does not change much over decades while others develop wrinkles earlier in life, due to increased collagen breakdown and glycation process. Sagging eyelids can become a frequent concern in some middle-aged and older adults. Numerous scientific studies demonstrated that skin aging has a strong genetic basis. With LifeNome’s DNA-based skin and hair care assessment and recommender, it could be explored how genetic makeup impacts skin during ageing and what actions could be taken to facilitate this process.

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SKIN PROFILE AND THE ENVIRONMENT

While environment, including diet, stress, age, hormones contribute to how skin looks and feels, genetics plays a large role in whether skin is inherently dry, or acne prone, risk of rosacea, eczema, and stretch marks. Genetic variants in key enzymes impact skin’s antioxidant capacity or inflammation. Variants in the genes that play key roles in skin protection, barrier function, and detoxification, may lead to irritations, premature aging, and early pigmented spots. With LifeNome’s DNA-based skin and hair care assessment and recommender, it could be explored how genetic makeup affects skin sensitivity to environmental factors, and how to use this knowledge to be more proactive about protecting the skin.

SKIN AND THE SUN

The sun plays an integral part in our well being and we draw our energy from it in various ways. One such example is when skin synthesizes sunlight to help manufacture Vitamin D. This vitamin is crucial for normal bone functioning and many other processes. While sunlight is life-giving, ultraviolet light (also found in sunlight) is detrimental and can age unprotected skin faster. Humans vary over 1000- fold in their sensitivity to the effects of ultraviolet radiation, and it is largely determined by their genetics. People with lighter skin already know that their skin burns when exposed to the sun, while people who tan well, and people with darker skin mistakenly assume that sun does not have a significant effect on their skin. With LifeNome’s DNA-based skin and hair care assessment and recommender, it could be explored how genetic makeup influences how the skin is impacted by sun exposure and what are the necessary measures to limit further damage.

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HAIR AND SCALP

Our genes profoundly influence hair appearance (colour, shape, density). Hair colour varies a lot in places like Western Europe, and East Asians tend to have strong straight hair while no one has straight hair in sub-Saharan Africa. Genetics also determines hair quality (growth, strength) and hair ageing (baldness, greying) we inherit from our parents. Hair traits are generally polygenic; they depend on many genetic variants, not just one or two. The hair of our dreams starts with the skin that covers our head. Just like overall skin, scalp skin quality and ageing depend on genetics. Also, stress, psychological factors, overuse of treatments and styling tools contribute to scalp conditions. Understanding scalp health and factors that contribute to it is significant for hair health. With LifeNome’s DNA-based skin and hair care assessment and recommender, it could be explored how genetic makeup influence hair and scalp characteristics and how to use this knowledge to be more proactive about hair/scalp care.

Insights and resources

The beauty industry is challenged by the need for the adaptive personalisation of the products to become genuinely responsive to consumers changing skin and hair/scalp care needs – hour by hour, day-to-day, month-to-month. Besides, there is growing consumer advocacy for non-toxic ingredients and greater transparency that leads toward a more risk-based approach for the assessment of ingredients and products. As a consequence, the industry is looking for incorporation of the more natural and sustainable ingredients to the new product lines.

LifeNome’s revolutionary Genomics AI™ technology is focusing on achieving genetic-based personalised skin and hair care by incorporating the complex scientific knowledge. Most of the existing genetic approaches rely on single genetic variation-single genetic trait association studies. LifeNome’s Genomics AI™ technology dynamically explores a network of DNA variations that influence potential genetic predisposition. LifeNome’s proprietary artificial intelligence algorithms use aggregate analysis of more than 2,500 scientific studies calibrated on tens of thousands of genomes. Skin and hair/scalp care predisposition assessments, recommendation and formulations are reviewed and certified by registered professionals